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Article

Functional domains for amelogenin revealed by compound genetic defects.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Mar 2003

Paine Michael L, Luo Wen, Zhu Dan-Hong, Bringas Pablo, Snead Malcolm L

Abstract excerpt

We have previously used the yeast two-hybrid assay and multiple in vitro methodologies to show that amelogenin undergoes self-assembly involving two domains (A and B). Using transgenic animals, we show that unique enamel phenotypes result from disruptions to either the A- or B-domain, supporting the role of amelogenin in influencing enamel structural organization. By crossbreeding, animals bearing two defective...

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Identifiers

PMID: 12619931
DOI: 10.1359/jbmr.2003.18.3.466
PMCID: PMC12931981

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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