Article
Prevalence of naturally occurring amino acid substitutions associated with resistance to hepatitis C virus NS3/NS4A protease inhibitors in São Paulo state.
Archives of virology - 1 Oct 2018
Moreira Regina Célia, de Torres Santos Ana Paula, Lisboa-Neto Gaspar, Mendes-Corrêa Maria Cássia Jacintho, Lemos Marcilio Figueiredo, Malta Fernanda Mello, Santana Rúbia Anita Ferraz, Dastoli Gregório Tadeu Fernando, de Castro Vanessa Fusco Duarte, Pinho João Renato Rebello
Abstract excerpt
Hepatitis C (HCV)-infected patients are treated with direct-acting antiviral agents (DAAs) in highly effective, well-tolerated, all-oral regimens. However, naturally occurring resistance-associated amino acid substitutions (RASs) may be selected during treatment. This study aimed to screen naturally occurring RASs NS3/NS4A inhibitors (PIs). Samples were obtained from DAA naïve patients, living in São Paulo state,...
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