Article
Angiotensin receptor type 1 polymorphism A1166C is associated with altered AT1R and miR-155 expression in carotid plaque tissue and development of hypoechoic carotid plaques.
Atherosclerosis - 1 May 2016
Stanković Aleksandra, Kolaković Ana, Živković Maja, Djurić Tamara, Bundalo Maja, Končar Igor, Davidović Lazar, Alavantić Dragan
Abstract excerpt
BACKGROUND AND AIMS: The principal biologic effects of the renin-angiotensin system are mediated by activation of the AT1R receptor. The microRNA miR-155 regulates AT1R expression, with both its, and AT1R's activity, linked to atherosclerosis. Target sites for miR-155 lie within the 3' UTR of the human AT1R gene, and include the AT1R A1166C polymorphism. Thus far, only levels of circulating miR-155 have been...
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