Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of interactions between mismatch repair initiation factors and the replication processivity factor PCNA.

Journal of molecular biology - 13 Jan 2006

Lee Susan D, Alani Eric

Abstract excerpt

In eukaryotes, the DNA replication factor PCNA is loaded onto primer-template junctions to act as a processivity factor for DNA polymerases. Genetic and biochemical studies suggest that PCNA also functions in early steps in mismatch repair (MMR) to facilitate the repair of misincorporation errors generated during DNA replication. These studies have shown that PCNA interacts directly with several MMR components,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Motifs
Share to Base Pair Mismatch
Share to DNA, Fungal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to MutL Protein Homolog 1

Share to MutL Proteins

Share to MutS Homolog 2 Protein

Share to Proliferating Cell Nuclear Antigen

Share to Surface Plasmon Resonance

Source

Identifiers

PMID: 16303135
DOI: 10.1016/j.jmb.2005.10.059

Genes

PCNA
MLH1
PMS1
EXO1
MSH3
MSH6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of interactions between mismatch repair initiation factors and the replication processivity factor PCNA.PMID 16303135Read ↗

DNA MISMATCH REPAIRSemantic proximity Read ↗

The Mlh1-Pms1 endonuclease uses ATP to preserve DNA discontinuities as strand discrimination signals to facilitate mismatch repairSemantic proximity Read ↗

ATP-dependent interaction of human mismatch repair proteins and dual role of PCNA in mismatch repairSemantic proximity Read ↗

Intrinsically disordered regions regulate both catalytic and non-catalytic activities of the MutLα mismatch repair complex.Semantic proximity Read ↗

Mismatch repair MLH complexes make distinct contributions to post-replicative mismatch repair versus trinucleotide repeat expansionsSemantic proximity Read ↗

Ligation of newly replicated DNA controls the timing of DNA mismatch repairSemantic proximity Read ↗

Human Mismatch Repair Protein MSH6 Contains a PWWP Domain That Targets Double Stranded DNASemantic proximity Read ↗

Interaction of proliferating cell nuclear antigen with PMS2 is required for MutLα activation and function in mismatch repairSemantic proximity Read ↗

Dynamic human MutSα–MutLα complexes compact mismatched DNASemantic proximity Read ↗

Disruption of protein-protein interaction hotspots in the C-terminal domain of MLH1 confers mismatch repair deficiency.Semantic proximity Read ↗

The Eukaryotic Mismatch Recognition Complexes Track with the Replisome during DNA Synthesis.Semantic proximity Read ↗

Characterization of a highly conserved binding site of Mlh1 required for exonuclease I-dependent mismatch repair.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.