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Article

Loss of circadian clock accelerates aging in neurodegeneration-prone mutants.

Neurobiology of disease - 1 Mar 2012

Krishnan Natraj, Rakshit Kuntol, Chow Eileen S, Wentzell Jill S, Kretzschmar Doris, Giebultowicz Jadwiga M

Abstract excerpt

Circadian clocks generate rhythms in molecular, cellular, physiological, and behavioral processes. Recent studies suggest that disruption of the clock mechanism accelerates organismal senescence and age-related pathologies in mammals. Impaired circadian rhythms are observed in many neurological diseases; however, it is not clear whether loss of rhythms is the cause or result of neurodegeneration, or both. To...

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Identifiers

PMID: 22227001
DOI: 10.1016/j.nbd.2011.12.034
PMCID: PMC3291167

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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