[Presence of the double pfmdr1 mutation 86Tyr and 1246 Tyr in clones of a chloroquine-resistant west African isolate of Plasmodium falciparum].

Article

[Presence of the double pfmdr1 mutation 86Tyr and 1246 Tyr in clones of a chloroquine-resistant west African isolate of Plasmodium falciparum].

Acta medica portuguesa - 1 Jan 2000

Pinheiro L, Franco S, Adagu I S, Rosa R, Rosário V E, Warhurst D C

Abstract excerpt

Isolates of Plasmodium falciparum from three areas of West Africa were recovered from cryopreservation and their chloroquine-sensitivity were determined in vitro. Of the 90 samples studied, 60 were from Guinea-Bissau (30Resistant/30Sensitive), 15 were from S. Tomé and Príncipe (11Resistant/4Sensi...

Topics

Africa, Western
Antimalarials
Chloroquine
Drug Resistance
Humans
Multidrug Resistance-Associated Proteins
Mutation
Plasmodium falciparum

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