Article
Translation of hepatitis B virus DNA polymerase from the internal AUG codon, not from the upstream AUG codon for the core protein.
Biochemical and biophysical research communications - 28 Sept 1990
Kawamoto S, Yamamoto S, Ueda K, Nagahata T, Chisaka O, Matsubara K
Abstract excerpt
Hepatitis B virus DNA replicates via its own polymerase that also acts as reverse transcriptase (Summers and Mason, 1982). This enzyme is encoded by a 3.5 Kb mRNA transcript covering the whole genome. Since the same transcript also codes for the core protein, and since the core open reading frame (ORF) is located upstream of the pol ORF, it has been suggested that the polymerase is first produced as a core-pol...
Topics
- Base Sequence
- Cell Line
- Codon
- DNA-Directed DNA Polymerase
- Genes, Viral
- Hepatitis B virus
- Humans
- Molecular Sequence Data
- Mutation
- Oligonucleotide Probes
- Protein Biosynthesis