Article
Mechanism of translation of the hepadnaviral polymerase (P) gene.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jul 1990
Chang L J, Ganem D, Varmus H E
Abstract excerpt
Unlike many other reverse transcriptase genes, the polymerase (P) gene of the hepatitis B viruses is expressed by translational initiation from its own AUG codon rather than by ribosomal frameshifting during translation of the overlapping core gene (C). To explore the mechanism of its translation, we have fused the P gene of duck hepatitis B virus to the bacterial lacZ gene at a point 3' to the C-P overlap; this...
Topics
- Animals
- Base Sequence
- Cell Line
- Codon
- Genes, Viral
- Hepadnaviridae
- Molecular Sequence Data
- Mutation
- Plasmids
- Poliovirus
- Protein Biosynthesis
- RNA, Messenger