cis rescue of a mutated reverse transcriptase gene of human hepatitis B virus by creation of an internal ATG.

doi:10.1128/JVI.64.3.1063-1069.1990

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Article

cis rescue of a mutated reverse transcriptase gene of human hepatitis B virus by creation of an internal ATG.

Journal of virology - 1 Mar 1990

Roychoudhury S, Shih C

Abstract excerpt

Using mutational analysis, we have investigated the translation strategy of the reverse transcriptase gene (pol) of human hepatitis B virus. It has been proposed that this pol gene product is synthesized as a core-pol fusion protein from a polycistronic mRNA template via ribosomal frameshifting, a mechanism often seen in retroelements. Our data indicate that creation of a novel ATG initiation codon near the...

Topics

Base Sequence
Carcinoma, Hepatocellular
Cell Line
DNA, Viral
Genes
Genes, Lethal
Genes, Viral
Genetic Vectors
Hepatitis B virus
Humans
Liver Neoplasms
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Oligonucleotide Probes

Protein Biosynthesis

RNA, Messenger

RNA-Directed DNA Polymerase

Templates, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 1689389
DOI: 10.1128/JVI.64.3.1063-1069.1990
PMCID: PMC249218

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1689389-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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