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Article

cis rescue of a mutated reverse transcriptase gene of human hepatitis B virus by creation of an internal ATG.

Journal of virology - 1 Mar 1990

Roychoudhury S, Shih C

Abstract excerpt

Using mutational analysis, we have investigated the translation strategy of the reverse transcriptase gene (pol) of human hepatitis B virus. It has been proposed that this pol gene product is synthesized as a core-pol fusion protein from a polycistronic mRNA template via ribosomal frameshifting, a mechanism often seen in retroelements. Our data indicate that creation of a novel ATG initiation codon near the...

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Identifiers

PMID: 1689389
DOI: 10.1128/JVI.64.3.1063-1069.1990
PMCID: PMC249218

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