Article
Poliovirus chimeras replicating under the translational control of genetic elements of hepatitis C virus reveal unusual properties of the internal ribosomal entry site of hepatitis C virus.
Proceedings of the National Academy of Sciences of the United States of America - 20 Feb 1996
Lu H H, Wimmer E
Abstract excerpt
Chimeric genomes of poliovirus (PV) have been constructed in which the cognate internal ribosomal entry site (IRES) element was replaced by genetic elements of hepatitis C virus (HCV). Replacement of PV IRES with nt 9-332 of the genotype Ib HCV genome, a sequence comprising all but the first eigh...
Topics
- Base Sequence
- Binding Sites
- Gene Expression Regulation, Viral
- HeLa Cells
- Hepacivirus
- Humans
- Molecular Sequence Data
- Mutagenesis
- Phenotype
- Poliovirus
- Protein Biosynthesis