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Article

A method to infer positive selection from marker dynamics in an asexual population.

Bioinformatics (Oxford, England) - 15 Mar 2012

Illingworth Christopher J R, Mustonen Ville

Abstract excerpt

MOTIVATION: The observation of positive selection acting on a mutant indicates that the corresponding mutation has some form of functional relevance. Determining the fitness effects of mutations thus has relevance to many interesting biological questions. One means of identifying beneficial mutations in an asexual population is to observe changes in the frequency of marked subsets of the population. We here...

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PMID: 22223745
DOI: 10.1093/bioinformatics/btr722
PMCID: PMC3307107

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