Article
Estimation of the rate and effect of new beneficial mutations in asexual populations.
Theoretical population biology - 1 Mar 2012
Zhang Wei, Sehgal Vasudha, Dinh Duy M, Azevedo Ricardo B R, Cooper Tim F, Azencott Robert
Abstract excerpt
The rate and effect of available beneficial mutations are key parameters in determining how a population adapts to a new environment. However, these parameters are poorly known, in large part because of the difficulty of designing and interpreting experiments to examine the rare and intrinsically stochastic process of mutation occurrence. We present a new approach to estimate the rate and selective advantage of...
Topics
- Bacteria
- Confidence Intervals
- Evolution, Molecular
- Genetic Fitness
- Genetic Markers
- Genotype
- Humans
- Markov Chains
- Models, Genetic
- Mutation
- Population Dynamics