Article
Infant rat infection modifies phenotypic properties of an invasive nontypeable Haemophilus influenzae.
Microbes and infection - 1 Jun 2012
Tsao David, Nelson Kevin L, Kim Daniel, Smith Arnold L
Abstract excerpt
Enhancing the virulence trait of a specific bacterium in an animal model is often performed prior to the use of the strain for ex vivo human studies, such as reactivity with complement and antibody, or with phagocytic cells. For example, in Streptococcus pneumoniae mouse passage is used to enhance capsule production. While investigating an unusual serum-resistant unencapsulated Haemophilus influenzae (R2866), we...
Topics
- Adult
- Animals
- Animals, Newborn
- Bacterial Proteins
- Blood Bactericidal Activity
- Cell Line
- Conjunctiva
- Female
- Haemophilus Infections
- Haemophilus influenzae
- Humans
- Inhibitory Concentration 50
- Lipopolysaccharides
- Microbial Viability
- Phenotype
- Pregnancy
- Rats
- Serial Passage