Article
Demonstration of lipooligosaccharide immunotype and capsule as virulence factors for Neisseria meningitidis using an infant mouse intranasal infection model.
Microbial pathogenesis - 1 Nov 1993
Mackinnon F G, Borrow R, Gorringe A R, Fox A J, Jones D M, Robinson A
Abstract excerpt
Using an infant mouse intranasal infection model, we have compared the virulence of 17 epidemiologically related isolates of Neisseria meningitidis associated with an outbreak of meningococcal disease in Gloucestershire, UK, and one German isolate. The isolates were all of serotype 15 subtype P1:...
Topics
- Administration, Intranasal
- Animals
- Antigens, Bacterial
- England
- Germany
- Lipopolysaccharides
- Meningitis, Meningococcal
- Mice
- Nasopharynx
- Neisseria meningitidis
- Phenotype
- Polymorphism, Restriction Fragment Length
- Polysaccharides, Bacterial
- Serotyping
- Virulence