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Enhanced Bacteremia in Human Factor H Transgenic Rats Infected by Neisseria meningitidis

22 Nov 2011

Abstract excerpt

Neisseria meningitidis binds the complement downregulating protein, factor H (fH), which enables the organism to evade host defenses. Two fH ligands, fHbp and NspA, are known to bind specifically to human fH. We developed a human fH transgenic infant rat model to investigate the effect of human fH on meningococcal bacteremia. At 18 h after intraperitoneal challenge with 560 CFU of group B strain H44/76, all 19...

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PMID: 22104107
DOI: 10.1128/iai.05604-11

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