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Article

Neurohormonal signalling pathways and the regulation of Alzheimer beta-amyloid metabolism.

Novartis Foundation symposium - 1 Jan 2000

Gandy S, Petanceska S

Abstract excerpt

Alzheimer's disease (AD) is characterized by the intracranial accumulation of the 4 kDa amyloid beta peptide (A beta), following proteolysis of a approximately 700 amino acid, integral membrane precursor, the amyloid beta precursor protein (APP). The best evidence causally linking APP to AD has been provided by the discovery of mutations within the APP coding sequence that segregate with disease phenotypes in...

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Identifiers

PMID: 10965512
DOI: 10.1002/0470870818.ch17

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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