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Article

Drosophila Polycomb complexes restrict neuroblast competence to generate motoneurons.

Development (Cambridge, England) - 1 Feb 2012

Touma Johnny J, Weckerle Frank F, Cleary Michael D

Abstract excerpt

Similar to mammalian neural progenitors, Drosophila neuroblasts progressively lose competence to make early-born neurons. In neuroblast 7-1 (NB7-1), Kruppel (Kr) specifies the third-born U3 motoneuron and Kr misexpression induces ectopic U3 cells. However, competence to generate U3 cells is limited to early divisions, when the Eve(+) U motoneurons are produced, and competence is lost when NB7-1 transitions to...

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Identifiers

PMID: 22219354
DOI: 10.1242/dev.071589

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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