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Article

Hierarchical deployment of factors regulating temporal fate in a diverse neuronal lineage of the Drosophila central brain.

Neuron - 23 Feb 2012

Kao Chih-Fei, Yu Hung-Hsiang, He Yisheng, Kao Jui-Chun, Lee Tzumin

Abstract excerpt

The anterodorsal projection neuron lineage of Drosophila melanogaster produces 40 neuronal types in a stereotypic order. Here we take advantage of this complete lineage sequence to examine the role of known temporal fating factors, including Chinmo and the Hb/Kr/Pdm/Cas transcriptional cascade, within this diverse central brain lineage. Kr mutation affects the temporal fate of the neuroblast (NB) itself, causing...

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Identifiers

PMID: 22365543
DOI: 10.1016/j.neuron.2011.12.018
PMCID: PMC3566789

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