Article
Liver-specific Commd1 knockout mice are susceptible to hepatic copper accumulation.
PloS one - 1 Jan 2011
Vonk Willianne I M, Bartuzi Paulina, de Bie Prim, Kloosterhuis Niels, Wichers Catharina G K, Berger Ruud, Haywood Susan, Klomp Leo W J, Wijmenga Cisca, van de Sluis Bart
Abstract excerpt
Canine copper toxicosis is an autosomal recessive disorder characterized by hepatic copper accumulation resulting in liver fibrosis and eventually cirrhosis. We have identified COMMD1 as the gene underlying copper toxicosis in Bedlington terriers. Although recent studies suggest that COMMD1 regulates hepatic copper export via an interaction with the Wilson disease protein ATP7B, its importance in hepatic copper...
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