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Article

Regulation of murine copper homeostasis by members of the COMMD protein family.

Disease models & mechanisms - 1 Jan 2021

Singla Amika, Chen Qing, Suzuki Kohei, Song Jie, Fedoseienko Alina, Wijers Melinde, Lopez Adam, Billadeau Daniel D, van de Sluis Bart, Burstein Ezra

Abstract excerpt

Copper is an essential transition metal for all eukaryotes. In mammals, intestinal copper absorption is mediated by the ATP7A copper transporter, whereas copper excretion occurs predominantly through the biliary route and is mediated by the paralog ATP7B. Both transporters have been shown to be recycled actively between the endosomal network and the plasma membrane by a molecular machinery known as the...

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Identifiers

PMID: 33262129
DOI: 10.1242/dmm.045963
PMCID: PMC7803461

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Regulation of murine copper homeostasis by members of the COMMD protein family.PMID 33262129Read ↗

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