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Article

Wnt5a regulates directional cell migration and cell proliferation via Ror2-mediated noncanonical pathway in mammalian palate development.

Development (Cambridge, England) - 1 Dec 2008

He Fenglei, Xiong Wei, Yu Xueyan, Espinoza-Lewis Ramon, Liu Chao, Gu Shuping, Nishita Michiru, Suzuki Kentaro, Yamada Gen, Minami Yasuhiro, Chen Yiping

Abstract excerpt

Tissue and molecular heterogeneities are present in the developing secondary palate along the anteroposterior (AP) axis in mice. Here, we show that Wnt5a and its receptor Ror2 are expressed in a graded manner along the AP axis of the palate. Wnt5a deficiency leads to a complete cleft of the secondary palate, which exhibits distinct phenotypic alterations at histological, cellular and molecular levels in the...

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Identifiers

PMID: 18948417
DOI: 10.1242/dev.025767
PMCID: PMC3010758

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