Article
The role of G protein gene GNB3 C825T polymorphism in HIV-1 acquisition, progression and immune activation.
Retrovirology - 3 Jan 2012
Juno Jennifer, Tuff Jeffrey, Choi Robert, Card Catherine, Kimani Joshua, Wachihi Charles, Koesters-Kiazyk Sandra, Ball T Blake, Farquhar Carey, Plummer Francis A, John-Stewart Grace, Luo Ma, Fowke Keith R
Abstract excerpt
BACKGROUND: The GNB3 C825T polymorphism is associated with increased G protein-mediated signal transduction, SDF-1α-mediated lymphocyte chemotaxis, accelerated HIV-1 progression, and altered responses to antiretroviral therapy among Caucasian subjects. The GNB3 825T allele is highly prevalent in African populations, and as such any impact on HIV-1 acquisition or progression rates could have a dramatic impact....
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