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In vivo generation of neural tumors from neoplastic pluripotent stem cells models early human pediatric brain tumor formation.

Stem cells (Dayton, Ohio) - 1 Mar 2012

Werbowetski-Ogilvie Tamra E, Morrison Ludivine Coudière, Fiebig-Comyn Aline, Bhatia Mickie

Abstract excerpt

Recent studies have identified gene signatures in malignant tumors that are associated with human embryonic stem cells, suggesting a molecular relationship between aggressive cancers and pluripotency. Here, we characterize neural precursors (NPs) derived from transformed human embryonic stem cells (N-t-hESCs) that exhibit neoplastic features of human brain tumors. NPs derived from t-hESCs have enhanced cell...

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PMID: 22213600
DOI: 10.1002/stem.1017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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