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Article

Genetic alterations and in vivo tumorigenicity of neurospheres derived from an adult glioblastoma.

1 Jan 2004

Abstract excerpt

Pediatric brain tumors may originate from cells endowed with neural stem/precursor cell properties, growing in vitro as neurospheres. We have found that these cells can also be present in adult brain tumors and form highly infiltrating gliomas in the brain of immunodeficient mice. Neurospheres were grown from three adult brain tumors and two pediatric gliomas. Differentiation of the neurospheres from one adult...

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PMID: 15469606
DOI: 10.1186/1476-4598-3-25

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