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Article

Variations in the exome of the LNCaP prostate cancer cell line.

The Prostate - 1 Sept 2012

Spans Lien, Atak Zeynep Kalender, Van Nieuwerburgh Filip, Deforce Dieter, Lerut Evelyne, Aerts Stein, Claessens Frank

Abstract excerpt

BACKGROUND: The LNCaP cell line is widely used as a model for prostate cancer. However, information on protein-changing mutations, genetic heterogeneity and genetic (in)stability is largely lacking for these cells. METHODS: Next-generation sequencing of the LNCaP exome revealed many single nucleotide variants (SNVs). To help identify the mutations that are most likely drivers of the oncogenic process, we...

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Share to Cell Line, Tumor
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Share to CDK4 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genetic Variation

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Share to Polymorphism, Single Nucleotide

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Source

Identifiers

PMID: 22213130
DOI: 10.1002/pros.22480

Genes

CDK4
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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