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Article

A new association test based on Chi-square partition for case-control GWA studies.

Genetic epidemiology - 1 Nov 2011

Chen Zhongxue

Abstract excerpt

In case-control genetic association studies, the robust procedure, Pearson's Chi-square test, is commonly used for testing association between disease status and genetic markers. However, this test does not take the possible trend of relative risks, which are due to genotype, into account. On the contrary, although Cochran-Armitage trend test with optimal scores is more powerful; it is usually difficult to assign...

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PMID: 22009790
DOI: 10.1002/gepi.20615

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