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Article

Notch signaling is antagonized by SAO-1, a novel GYF-domain protein that interacts with the E3 ubiquitin ligase SEL-10 in Caenorhabditis elegans.

Genetics - 1 Mar 2012

Hale Valerie A, Guiney Evan L, Goldberg Lindsey Y, Haduong Josephine H, Kwartler Callie S, Scangos Katherine W, Goutte Caroline

Abstract excerpt

Notch signaling pathways can be regulated through a variety of cellular mechanisms, and genetically compromised systems provide useful platforms from which to search for the responsible modulators. The Caenorhabditis elegans gene aph-1 encodes a component of γ-secretase, which is essential for Notch signaling events throughout development. By looking for suppressors of the incompletely penetrant aph-1(zu147)...

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Identifiers

PMID: 22209900
DOI: 10.1534/genetics.111.136804
PMCID: PMC3296241

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Notch signaling is antagonized by SAO-1, a novel GYF-domain protein that interacts with the E3 ubiquitin ligase SEL-10 in Caenorhabditis elegans.PMID 22209900Read ↗

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