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Article

Hippocampal volume and the AKT signaling system in first-episode schizophrenia.

Journal of psychiatric research - 1 Mar 2012

Szamosi András, Kelemen Oguz, Kéri Szabolcs

Abstract excerpt

OBJECTIVE: The phosphoinositide 3'-kinase (PI3K)--protein kinase B (AKT1)--glycogen synthase kinase (GSK)-3β system is modulated by several factors implicated in the pathophysiology of schizophrenia. Evidence suggests that neuregulin 1 (NRG1) induces decreased AKT phosphorylation in schizophrenia relative to healthy controls, which may be related to dysfunctional neurodevelopment and neuroplasticity. The aim of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22209534
DOI: 10.1016/j.jpsychires.2011.12.005

Genes

NRG1
AKT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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