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Article

Misfolded G Protein-Coupled Receptors and Endocrine Disease. Molecular Mechanisms and Therapeutic Prospects.

International journal of molecular sciences - 15 Nov 2021

Ulloa-Aguirre Alfredo, Zariñán Teresa, Jardón-Valadez Eduardo

Abstract excerpt

Misfolding of G protein-coupled receptors (GPCRs) caused by mutations frequently leads to disease due to intracellular trapping of the conformationally abnormal receptor. Several endocrine diseases due to inactivating mutations in GPCRs have been described, including X-linked nephrogenic diabetes insipidus, thyroid disorders, familial hypocalciuric hypercalcemia, obesity, familial glucocorticoid deficiency...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34830210
DOI: 10.3390/ijms222212329
PMCID: PMC8622668

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