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Article

The inference of phased haplotypes for the immunoglobulin H chain V region gene loci by analysis of VDJ gene rearrangements.

Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 2012

Kidd Marie J, Chen Zhiliang, Wang Yan, Jackson Katherine J, Zhang Lyndon, Boyd Scott D, Fire Andrew Z, Tanaka Mark M, Gaëta Bruno A, Collins Andrew M

Abstract excerpt

The existence of many highly similar genes in the lymphocyte receptor gene loci makes them difficult to investigate, and the determination of phased "haplotypes" has been particularly problematic. However, V(D)J gene rearrangements provide an opportunity to infer the association of Ig genes along the chromosomes. The chromosomal distribution of H chain genes in an Ig genotype can be inferred through analysis of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22205028
DOI: 10.4049/jimmunol.1102097
PMCID: PMC4734744

Genes

IGH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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