No evidence for the use of DIR, D–D fusions, chromosome 15 open reading frames or V_Hreplacement in the peripheral repertoire was found on application of an improved algorithm, JointML<i>,</i> to 6329 human immunoglobulin H rearrangements

Abstract excerpt

Antibody diversity is created by imprecise joining of the variability (V), diversity (D) and joining (J) gene segments of the heavy and light chain loci. Analysis of rearrangements is complicated by somatic hypermutations and uncertainty concerning the sources of gene segments and the precise way in which they recombine. It has been suggested that D genes with irregular recombination signal sequences (DIR) and...

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