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Article

Polymorphism of the human Ig VH4 gene family.

Journal of immunology (Baltimore, Md. : 1950) - 15 May 1991

van Dijk K W, Sasso E H, Milner E C

Abstract excerpt

In this study, we analyze the human VH4 gene family and find it to exhibit a level of polymorphism similar to that of the much larger VH3 family. A cloned VH4 probe detected an average of 10 hybridizing BgIII restriction fragments in genomic DNA derived from 75 unrelated individuals and a total of 15 distinct bands. Of these 15 restriction fragments, 12 were polymorphic, as demonstrated by band absence in some...

Topics

Alleles
Female
Genes, Immunoglobulin
Haplotypes
Heterozygote
Homozygote
Humans
Immunoglobulin Heavy Chains
Immunoglobulin Variable Region
Male
Polymorphism, Genetic
Polymorphism, Restriction Fragment Length

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 1673987

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CDR2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1673987-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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