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Article

Enhanced Directional Migration of Cancer Stem Cells in 3D Aligned Collagen Matrices.

Biophysical journal - 14 Mar 2017

Ray Arja, Slama Zachary M, Morford Rachel K, Madden Samantha A, Provenzano Paolo P

Abstract excerpt

Directed cell migration by contact guidance in aligned collagenous extracellular matrix (ECM) is a critical enabler of breast cancer dissemination. The mechanisms of this process are poorly understood, particularly in 3D, in part because of the lack of efficient methods to generate aligned collagen matrices. To address this technological gap, we propose a simple method to align collagen gels using guided cellular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28297639
DOI: 10.1016/j.bpj.2017.01.007
PMCID: PMC5355487

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