Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comparable fitness and transmissibility between oseltamivir-resistant pandemic 2009 and seasonal H1N1 influenza viruses with the H275Y neuraminidase mutation.

Journal of virology - 1 Oct 2012

Wong Diana D Y, Choy Ka-Tim, Chan Renee W Y, Sia Sin Fun, Chiu Hsin-Ping, Cheung Peter P H, Chan Michael C W, Peiris J S Malik, Yen Hui-Ling

Abstract excerpt

Limited antiviral compounds are available for the control of influenza, and the emergence of resistant variants would further narrow the options for defense. The H275Y neuraminidase (NA) mutation, which confers resistance to oseltamivir carboxylate, has been identified among the seasonal H1N1 and 2009 pandemic influenza viruses; however, those H275Y resistant variants demonstrated distinct epidemiological...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens
Share to Dogs

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Viral

Share to Ferrets

Share to Influenza A Virus, H1N1 Subtype

Share to Mucins

Share to Neuraminidase

Share to Oseltamivir

Source

Open in PubMed Open full text

Identifiers

PMID: 22811535
DOI: 10.1128/JVI.00985-12
PMCID: PMC3457312

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comparable fitness and transmissibility between oseltamivir-resistant pandemic 2009 and seasonal H1N1 influenza viruses with the H275Y neuraminidase mutation.PMID 22811535Read ↗

Effect of the Neuraminidase Mutation H274Y Conferring Resistance to Oseltamivir on the Replicative Capacity and Virulence of Old and Recent Human Influenza A(H1N1) VirusesSemantic proximity Read ↗

Role of permissive neuraminidase mutations in influenza A/Brisbane/59/2007-like (H1N1) viruses.Semantic proximity Read ↗

Oseltamivir-Resistant Pandemic A/H1N1 Virus Is as Virulent as Its Wild-Type Counterpart in Mice and FerretsSemantic proximity Read ↗

Comparison of early and recent influenza A(H1N1)pdm09 isolates harboring or not the H275Y neuraminidase mutation, in vitro and in animal models.Semantic proximity Read ↗

Pandemic H1N1 2009 influenza virus with the H275Y oseltamivir resistance neuraminidase mutation shows a small compromise in enzyme activity and viral fitnessSemantic proximity Read ↗

MultiDrug-Resistant 2009 Pandemic Influenza A(H1N1) Viruses Maintain Fitness and Transmissibility in FerretsSemantic proximity Read ↗

The R292K Mutation That Confers Resistance to Neuraminidase Inhibitors Leads to Competitive Fitness Loss of A/Shanghai/1/2013 (H7N9) Influenza Virus in FerretsSemantic proximity Read ↗

Impact of a large deletion in the neuraminidase protein identified in a laninamivir-selected influenza A/Brisbane/10/2007 (H3N2) variant on viral fitness in vitro and in ferrets.Semantic proximity Read ↗

Characterization of oseltamivir-resistant 2009 H1N1 pandemic influenza A viruses.Semantic proximity Read ↗

Oseltamivir-Resistant Variants of the 2009 Pandemic H1N1 Influenza A Virus Are Not Attenuated in the Guinea Pig and Ferret Transmission ModelsSemantic proximity Read ↗

Neuraminidase inhibitor-resistant influenza viruses may differ substantially in fitness and transmissibility.Semantic proximity Read ↗

The H275Y neuraminidase mutation of the pandemic A/H1N1 influenza virus lengthens the eclipse phase and reduces viral output of infected cells, potentially compromising fitness in ferrets.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.