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Article

Neuraminidase Mutations Conferring Resistance to Oseltamivir in Influenza A(H7N9) Viruses.

Journal of virology - 1 May 2015

Marjuki Henju, Mishin Vasiliy P, Chesnokov Anton P, De La Cruz Juan A, Davis Charles T, Villanueva Julie M, Fry Alicia M, Gubareva Larisa V

Abstract excerpt

UNLABELLED: Human infections by avian influenza A(H7N9) virus entail substantial morbidity and mortality. Treatment of infected patients with the neuraminidase (NA) inhibitor oseltamivir was associated with emergence of viruses carrying NA substitutions. In the NA inhibition (NI) assay, R292K conferred highly reduced inhibition by oseltamivir, while E119V and I222K each caused reduced inhibition. To facilitate...

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Source

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Identifiers

PMID: 25740997
DOI: 10.1128/JVI.03513-14
PMCID: PMC4442539

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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