Article
Multidrug resistant 2009 A/H1N1 influenza clinical isolate with a neuraminidase I223R mutation retains its virulence and transmissibility in ferrets.
PLoS pathogens - 1 Sept 2011
van der Vries Erhard, Veldhuis Kroeze Edwin J, Stittelaar Koert J, Linster Martin, Van der Linden Anne, Schrauwen Eefje J A, Leijten Lonneke M, van Amerongen Geert, Schutten Martin, Kuiken Thijs, Osterhaus Albert D M E, Fouchier Ron A M, Boucher Charles A B, Herfst Sander
Abstract excerpt
Only two classes of antiviral drugs, neuraminidase inhibitors and adamantanes, are approved for prophylaxis and therapy against influenza virus infections. A major concern is that influenza virus becomes resistant to these antiviral drugs and spreads in the human population. The 2009 pandemic A/H1N1 influenza virus is naturally resistant to adamantanes. Recently a novel neuraminidase I223R mutation was identified...
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