Article
Profiling of linker histone variants in ovarian cancer.
Frontiers in bioscience (Landmark edition) - 1 Jan 2012
Medrzycki Magdalena, Zhang Yunzhe, McDonald John F, Fan Yuhong
Abstract excerpt
H1 linker histones play a key role in facilitating higher order chromatin folding. Emerging evidence suggests that H1 and its multiple variants are important epigenetic factors in modulating chromatin function and gene expression. Ovarian cancer is a devastating disease, ranking the fifth leading cause of all women cancer death due to its poor prognosis and difficulty in early diagnosis. Although epigenetic...
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