Article
The omnipotent suppressor SUP45 affects nucleic acid metabolism and mitochondrial structure.
Yeast (Chichester, England) - 1 Jan 2000
Pocklington M J, Johnston L, Jenkins J R, Orr E
Abstract excerpt
Yeast (Saccharomyces cerevisiae) strains sensitive to a variety of drugs were used to select for novobiocin-resistant mutants that were simultaneously temperature-sensitive. The mutants remained as sensitive as the parent strains to a wide range of drugs other than novobiocin, and did not exhibit any suppression of suppressible auxotrophic markers. At the non-permissive temperature, the mutant cells arrested...
Topics
- Cloning, Molecular
- DNA, Fungal
- DNA, Mitochondrial
- Drug Resistance, Microbial
- Fungal Proteins
- Genes, Fungal
- Genes, Suppressor
- Microscopy, Fluorescence
- Mitochondria
- Mutation
- Novobiocin