Article
Genetic polymorphisms and cervical cancer development: ATM G5557A and p53bp1 C1236G.
Oncology reports - 1 Apr 2012
Oliveira S, Ribeiro J, Sousa H, Pinto D, Baldaque I, Medeiros R
Abstract excerpt
Persistent infections by high-risk types of human papillomavirus (HPV) have been established as the etiological agent of cervical cancer. The integration of the HPV genome into the host genome is a crucial step in cervical carcinogenesis, although, correct activation of DNA damage repair pathways will avoid the development of cancer. Recent data indicate that several polymorphisms of key regulators from the DNA...
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