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Article

Targeting cysteine-mediated dimerization of the MUC1-C oncoprotein in human cancer cells.

International journal of oncology - 1 May 2012

Raina Deepak, Ahmad Rehan, Rajabi Hasan, Panchamoorthy Govind, Kharbanda Surender, Kufe Donald

Abstract excerpt

The MUC1 heterodimeric protein is aberrantly overexpressed in diverse human carcinomas and contributes to the malignant phenotype. The MUC1-C transmembrane subunit contains a CQC motif in the cytoplasmic domain that has been implicated in the formation of dimers and in its oncogenic function. The present study demonstrates that MUC1-C forms dimers in human breast and lung cancer cells. MUC1-C dimerization was...

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Source

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Identifiers

PMID: 22200620
DOI: 10.3892/ijo.2011.1308
PMCID: PMC3326351

Genes

MUC1
CFP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

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