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Article

Characterization of the MUC1-C Cytoplasmic Domain as a Cancer Target

12 Aug 2015

Abstract excerpt

Mucin 1 (MUC1) is a heterodimeric protein that is aberrantly expressed in diverse human carcinomas and certain hematologic malignancies. The oncogenic MUC1 transmembrane C-terminal subunit (MUC1-C) functions in part by transducing growth and survival signals from cell surface receptors. However, little is known about the structure of the MUC1-C cytoplasmic domain as a potential drug target. Using methods for...

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PMID: 26267657
DOI: 10.1371/journal.pone.0135156

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