Article
MUC1/X protein immunization enhances cDNA immunization in generating anti-MUC1 alpha/beta junction antibodies that target malignant cells.
Cancer research - 1 Dec 2006
Rubinstein Daniel B, Karmely Maya, Ziv Ravit, Benhar Itai, Leitner Orit, Baron Shoshana, Katz Ben-Zion, Wreschner Daniel H
Abstract excerpt
MUC1 has generated considerable interest as a tumor marker and potential target for tumor killing. To date, most antibodies against MUC1 recognize epitopes within the highly immunogenic alpha chain tandem repeat array. A major shortcoming of such antibodies is that the MUC1 alpha chain is shed into the peripheral circulation, sequesters circulating antitandem repeat array antibodies, and limits their ability to...
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