Article
MUC1 membrane trafficking is modulated by multiple interactions.
The Journal of biological chemistry - 17 Dec 2004
Kinlough Carol L, Poland Paul A, Bruns James B, Harkleroad Keri L, Hughey Rebecca P
Abstract excerpt
MUC1 is a mucin-like transmembrane protein found on the apical surface of many epithelia. Because aberrant intracellular localization of MUC1 in tumor cells correlates with an aggressive tumor and a poor prognosis for the patient, experiments were designed to characterize the features that modulate MUC1 membrane trafficking. By following [(35)S]Met/Cys-labeled MUC1 in glycosylation-defective Chinese hamster ovary...
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