Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nuclear import of the MUC1-C oncoprotein is mediated by nucleoporin Nup62.

The Journal of biological chemistry - 6 Jul 2007

Leng Yumei, Cao Cheng, Ren Jian, Huang Lei, Chen Dongshu, Ito Masaki, Kufe Donald

Abstract excerpt

The MUC1 heterodimeric transmembrane protein is aberrantly overexpressed by most human carcinomas. The MUC1 C-terminal subunit (MUC1-C) is devoid of a classical nuclear localization signal and is targeted to the nucleus by an unknown mechanism. The present results demonstrate that MUC1-C associat...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Active Transport, Cell Nucleus
Share to alpha Karyopherins
Share to Antigens, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to beta Karyopherins

Share to Mucin-1

Share to Mucins

Share to Nuclear Pore Complex Proteins

Share to Oncogene Proteins

Source

Identifiers

PMID: 17500061
DOI: 10.1074/jbc.M703222200

Genes

MUC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17500061-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nuclear import of the MUC1-C oncoprotein is mediated by nucleoporin Nup62.PMID 17500061Read ↗

MUC1 Oncoprotein Regulates Bcr-Abl Stability and Pathogenesis in Chronic Myelogenous Leukemia CellsSemantic proximity Read ↗

Characterization of the MUC1-C Cytoplasmic Domain as a Cancer TargetSemantic proximity Read ↗

The NUP1 gene encodes an essential component of the yeast nuclear pore complex.Semantic proximity Read ↗

Targeting cysteine-mediated dimerization of the MUC1-C oncoprotein in human cancer cells.Semantic proximity Read ↗

MUC1 oncoprotein blocks nuclear targeting of c-Abl in the apoptotic response to DNA damage.Semantic proximity Read ↗

MUC1 intra-cellular trafficking is clathrin, dynamin, and rab5 dependent.Semantic proximity Read ↗

The Leber congenital amaurosis protein AIPL1 modulates the nuclear translocation of NUB1 and suppresses inclusion formation by NUB1 fragments.Semantic proximity Read ↗

MUC1-C Oncoprotein Induces TCF7L2 Transcription Factor Activation and Promotes Cyclin D1 Expression in Human Breast Cancer CellsSemantic proximity Read ↗

Nuclear mRNA export requires complex formation between Mex67p and Mtr2p at the nuclear pores.Semantic proximity Read ↗

MUC1-C Oncoprotein Promotes STAT3 Activation in an Autoinductive Regulatory LoopSemantic proximity Read ↗

Two yeast nuclear pore complex proteins involved in mRNA export form a cytoplasmically oriented subcomplex.Semantic proximity Read ↗

MUC1 membrane trafficking is modulated by multiple interactions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.