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Article

Nuclear import of the MUC1-C oncoprotein is mediated by nucleoporin Nup62.

The Journal of biological chemistry - 6 Jul 2007

Leng Yumei, Cao Cheng, Ren Jian, Huang Lei, Chen Dongshu, Ito Masaki, Kufe Donald

Abstract excerpt

The MUC1 heterodimeric transmembrane protein is aberrantly overexpressed by most human carcinomas. The MUC1 C-terminal subunit (MUC1-C) is devoid of a classical nuclear localization signal and is targeted to the nucleus by an unknown mechanism. The present results demonstrate that MUC1-C associates with importin beta and not importin alpha. The results also show that, like importin beta, MUC1-C binds to Nup62...

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Source

Identifiers

PMID: 17500061
DOI: 10.1074/jbc.M703222200

Genes

MUC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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