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Article

TLR1 polymorphisms in Europeans and spontaneous pregnancy loss.

Gene - 15 Feb 2012

Crişan Tania O, Farcaş Marius F, Trifa Adrian P, Plantinga Theo S, Militaru Mariela S, Pop Ioan V, Netea Mihai G, Popp Radu A

Abstract excerpt

Toll-like receptors (TLRs) are critical components of the pathogen recognition by the host innate immune system. Recently it has been shown that TLR1 is under evolutionary pressure in Europeans. This involves the positive selection of the nonsynonymous TLR1 1805G variant in Europeans, although this is associated with poor TLR1 response and unfavorable prognosis in various infections. In terms of natural...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22200569
DOI: 10.1016/j.gene.2011.12.008

Genes

TLR1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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