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Article

Evolution of Sindbis virus with a low-methionine-resistant phenotype is dependent both on a pre-existing mutation and on the methionine concentration in the medium.

PloS one - 1 Jan 2013

Stollar Victor, Mensah Virginia, Adams Sandra, Li Mei-Ling

Abstract excerpt

SVlm21 is a mutant of Sindbis virus which was isolated by serial passage of virus in mosquito cells maintained in low-methionine medium; it therefore has a low-methionine-resistant (LMR) phenotype. This phenotype requires mutations at nts 319 and 321; these mutations result in Arg to Leu and Ser to Cys changes at positions 87 and 88 respectively in the viral methyl transferase, nsP1. To better understand the...

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Identifiers

PMID: 23544150
DOI: 10.1371/journal.pone.0060504
PMCID: PMC3609753

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