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Article

Theiler's viruses with mutations in loop I of VP1 lead to altered tropism and pathogenesis.

Journal of virology - 1 Apr 1999

McCright I J, Tsunoda I, Whitby F G, Fujinami R S

Abstract excerpt

Theiler's murine encephalomyelitis viruses are picornaviruses that can infect the central nervous system. The DA strain produces an acute polioencephalomyelitis followed by a chronic demyelinating disease in its natural host, the mouse. The ability of DA virus to induce a demyelinating disease renders this virus infection a model for human demyelinating diseases such as multiple sclerosis. Here we describe the...

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Identifiers

PMID: 10074129
DOI: 10.1128/JVI.73.4.2814-2824.1999
PMCID: PMC104039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Theiler's viruses with mutations in loop I of VP1 lead to altered tropism and pathogenesis.PMID 10074129Read ↗

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