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Article

The differential effects of wild-type and mutated K-Ras on MST2 signaling are determined by K-Ras activation kinetics.

Molecular and cellular biology - 1 May 2013

Romano David, Maccario Helene, Doherty Carolanne, Quinn Niall P, Kolch Walter, Matallanas David

Abstract excerpt

K-Ras is frequently mutated in human cancers. Mutant (mt) K-Ras can stimulate both oncogenic transformation and apoptosis through activation of extracellular signal-regulated kinase (ERK) and AKT pathways and the MST2 pathway, respectively. The biological outcome is determined by the balance and...

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Identifiers

PMID: 23459937
DOI: 10.1128/MCB.01414-12
PMCID: PMC3624182

Genes

LATS1
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23459937-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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