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Article

Performance of the cobas EZH2 mutation test on clinical samples from non-Hodgkin lymphoma patients.

PloS one - 1 Jan 2023

Shyu Johnny Y, Schlag Peter A, Karwowska Sylwia M, Manohar Chitra F, Truong Huan M, Longshore John W, Zhang Guili

Abstract excerpt

OBJECTIVE: To present the technical verification and clinical validation of the companion diagnostic assay, cobas® EZH2 Mutation Test (cobas EZH2 Test), targeting gain-of-function EZH2 mutations in follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL). The focus is on patient clinical samples proving that the test met the performance criteria required for FDA approval of a companion diagnostic test....

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Share to DNA Mutational Analysis
Share to Enhancer of Zeste Homolog 2 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphoma, Follicular

Share to Lymphoma, Large B-Cell, Diffuse

Share to Mutation

Share to Reproducibility of Results

Source

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Identifiers

PMID: 38096164
DOI: 10.1371/journal.pone.0292251
PMCID: PMC10721068

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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