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Article

High-fat diet exacerbates renal dysfunction in SHR: reversal by induction of HO-1-adiponectin axis.

Obesity (Silver Spring, Md.) - 1 May 2012

Cao Jian, Inoue Kazuyoshi, Sodhi Komal, Puri Nitin, Peterson Stephen J, Rezzani Rita, Abraham Nader G

Abstract excerpt

High-dietary fat intake is a major risk factor for development of metabolic and cardiovascular-renal dysfunction including obesity, coronary artery disease, hypertension, and chronic renal failure. We examined the effect of a high-fat diet on renal function and morphology in spontaneously hypertensive rats (SHR), a phenotype designed to mimic metabolic syndrome. High-fat diet induced increase (P < 0.05) in blood...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22193921
DOI: 10.1038/oby.2011.365
PMCID: PMC5568548

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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